On the contrary, from 1967 and 1995, the Clomid package insert guaranteed prescribing doctors that they were no causative proof of a damaging effect of Clomid treatment on the human fetus. In the mid-1990s it was established that NTDs and other particular natural anomalies can happen when the early embryo is starved of a sufficient cholesterol supply. Apart from it being an essential constituent of the human cell, there is more. It was found out that a gene which dictates how some organs form during the early pregnancy period must combine with cholesterol for it to work properly.
This gene is the sonic hedgehog/Shh.
Without an adequate level of cholesterol, Shh cannot communicate properly and defects will occur. Finding out about the significance of cholesterol was a huge breakthrough in the development of embryonic organs. It has helped to understand more how a human embryo can become defect because of fertility drugs. It is yet to be vastly known that clomiphene citrate is a drug that inhibits cholesterol. It hinders the functioning of a certain body enzyme that changes desmosterol to cholesterol. Fertility drugs have a demonstrated ability to considerably raise normal estrogen levels. This is another suppressing of cholesterol in the critical beginning few weeks of pregnancy. The inverse correlation between estrogen and cholesterol level has been proven. Hence, the more the estrogen level, the lesser the cholesterol.
In the beginning of 2008, a study was published to demonstrate this. The researchers discovered that women that did not develop ovarian follicular cysts were open to clomiphene in the beginning 2 months of pregnancy. These women had a 350 % risk increase of conceiving a baby with an NTD. In addition, if the fertility drug had caused the development of ovarian cysts, that contains high estrogen levels, the occurrence of NTDs went higher up to a 540 % increase in risk.
The authors came to the conclusion that when complemented by follicular cysts, treating with clomiphene might have a hand in the creation of NTD. However, if it is administered before conception, it can be biologically active for about 54 days after consumption. Hence, it will be present in early pregnancy in every woman that conceives in the course of a treatment cycle. The sad thing about hiding this info from users of fertility drugs and their physician is that there presently exists a modest means to minimize birth defects risks while using these medications. Follow posts from Medicine Direct to be more informed .